Microsoft has said sales in the first three months of 2009 fell 6% from the previous year - its first quarterly drop in 23 years as a public company.
The world's largest software maker said profit dropped by 32% to $2.98bn (£2bn). Sales slipped to $13.65bn.
Microsoft makes most of its profit selling the Windows operating system and business software such as Office.
However demand has been hit by falling sales of personal computers as consumers and businesses trim spending.
Microsoft chief executive Steve Ballmer told the BBC World Service that its results had been "impacted" by the downturn in the world economy.
He also admitted the company would have had less total sales "than we would have had before the downturn".
"We expect the weakness to continue through at least the next quarter," said the firm's chief financial officer, Chris Liddell.